Mitochondria Dysfunction on Striatum After a Chronic Exposure to Pesticides Mixture in Rats

Cypermethrin (CYP) and Acetamiprid (AC) are two pesticides widely used in Algeria to eliminate insects that spoil crops and transport disease. In this study, the neurobehavioral effects induced by a mixture of the pesticides (CYP+AC) were tested at doses of 3.14 and 0.32 mg/kg for three months. The evaluation of mitochondrial oxidative stress on striatum tissues was recorded. According to the main results, CYP+AC mixture led to the disruption of mitochondrial parameters evaluated by a significant increase of MDAmit level, of GSTmit and SODmit activities, and a significant decrease of GSHmit level, CATmit and GPxmit activities. Due to disruption of some of mitochondria antioxidant enzymes, which may be the main cause of brain cell degeneration and decrease of learning and memorizing rate, the administration of CYP+AC mixture induced neurotoxicity.