The CUPID-Mo experiment at the Laboratoire Souterrain de Modane (France) is a demonstrator for CUPID, the next-generation ton-scale cryogenic $0\nu\beta\beta$ experiment. It consists of a 4.2 kg array of 20 enriched Li$_{2}$$^{100}$MoO$_4$ scintillating bolometers to search for the lepton number violating process of $0\nu\beta\beta$ decay in $^{100}$Mo. With more than one year of operation (2.16 kg$\times$yr of physics data), no event in the region of interest and hence no evidence for $0\nu\beta\beta$ is observed. We report a new limit on the half-life of $0\nu\beta\beta$ decay in $^{100}$Mo of $T_{1/2} > 1.5 \times 10^{24}\,$yr at 90 % C.I. The limit corresponds to an effective Majorana neutrino mass $\langle m_{\beta\beta} \rangle$ $<$ (0.31--0.54)$\,$eV, dependent on the nuclear matrix element in the light Majorana neutrino exchange interpretation.
