An observational study to evaluate the response and toxicity with conventional fractionation and hypo fractionated radiotherapy for locally advanced non small cell lung carcinoma following induction chemotherapy

Aims & Objectives: To evaluate the response and toxicity with Conventional fractionation and hypofractionated radiotherapy for locally advanced NSCLC following induction chemotherapy. To assess and compare following for locally advanced NSCLC with Conventional and hypo fractionated radiotherapy following induction chemotherapy. Materials And Methods: This prospective observational study was conducted at Saroj Gupta Cancer Centre and Research Institute, Kolkata; accrual was from June 2016 to September 2017. Data was collected from all patients who had been cytological / histopathologically and radiological proven stage III Non Small Cell Lung Carcinoma; fullling eligibility criteria, were recruited after obtaining informed consent. Results And Analysis: We found that the association between response at the END OF RT in two groups was not statistically signicant (p=0.8559). Association between Dermatitis highest grade at end of RT in two groups was not statistically signicant (p=0.5201). Association between Response 6 months after RT in two groups was not statistically signicant (p=0.7667). Association between Response 9 months after RT in two groups was not statistically signicant (p=0.9255). Association between Dermatitis. Conclusion & Summary: Our study showed hypofractionated radiotherapy is non-inferior to Conventional radiotherapy with equivalent overall response and toxicity and well tolerable. In patients with poor performance status who cannot tolerate concurrent chemo radiation, induction chemotherapy with hypofractionated radiotherapy regimen can be considered as a treatment of choice with manageable toxicities.