Effects of Microencapsulation on the Release and Permeation of Active Substances from Topical Preparations

Topical application involves application to a specific place on the skin where the given preparation manifests its effect. The properties of finished topical preparations and the incorporated active substances can often change due to various environmental and intrinsic factors. In order to prevent these changes and at the same time improve the efficacy and stability of the preparation, a large number of microencapsulation methods have been developed for the production of microparticles (microcapsules and microspheres) as a delivery system. The results of the study showed that microencapsulation achieves control of the permeation of substances in such a way that the substances remain on the surface of the skin or within a certain layer of the skin where they exert their action. Controlled release of the substances has also been achieved, thus ensuring better efficacy and reducing toxicity.