Bacterial mitigation strategies: impact of pathogen reduction and large-volume sampling on platelet productivity

Background: As blood centers evaluate strategies to further mitigate the risk of bacterial contamination and septic transfusion reactions associated with platelets, modeling provides valuable information in terms of impact to apheresis platelet productivity. A real-world donor database was used to model platelet productivity to provide a comparison of large-volume delayed sampling (LVDS) and pathogen reduction (PR) as well as platelet transfusion dose.