Effect of exercise on lipid profile in males and females with a history of obesity in their first-degree relative

Background: Parental obesity is a major determinant of lipid profile in individuals. Long-term derangement of lipid profile can lead to increase in cardiovascular morbidity and mortality. Regular exercise can help to control the lipid profile in normal range. Aims and Objective: This study aims to see the effect of moderate intensity of exercise on lipid profile in both males and females with positive family history of obesity in their first-degree relatives (mother, father, or both). Materials and Methods: A total of 79 young, apparently healthy including 51 males and 28 females volunteer were selected in the study. The first-degree relative with body mass index >25 kg/m2 was considered as positive family history of obesity. Blood samples were taken for baseline lipid profile assessment then each subject had performed 30 min of moderate intensity exercise through cycle ergometer for 3 weeks. After 3 weeks of exercise, blood sample again collected. The estimation of serum lipid profile level was done in the pathology department. Results: Statistically significant reduction was observed between pre- and post-exercise blood triglycerides and very low-density lipoprotein (LDL) levels in males. No statistically significant differences were observed between pre- and post-exercise blood cholesterol, high-density lipoprotein, and LDL levels in males, and pre- and post-exercise blood lipid profile levels in females. History of obesity in first-degree relative does not have direct impact on lipid profile in both genders. Conclusion: Lifestyle modification including exercise protocol and dietary restrictions has shown remarkable beneficial changes in each parameter of lipid profile according to literature.