Expression Profile of Long Non Coding RNA PVT1 in Patients with Ulcerative Colitis

Background: Ulcerative colitis (UC) is a chronic progressive inflammatory bowel disease, many long non coding RNA (lncRNAs) have been studied to have a role in the pathogenesis of Ulcerative colitis. Objective: is to evaluate expression level of long noncoding RNA PVT1 in ulcerative colitis and its association with the severity of the disease. Methodology: Sixty ulcerative colitis patients and 60 subjects were enrolled as controls. LNCRNA PVT1 relative expression level was tested using miScript SYBR Green PCR Kit. Results: Results showed significant differences between the patients with ulcerative colitis and controls as regard the median of the relative expression level of LNC PVT1 (P<0.0001). Also, there were positive significant correlations between the expression level of LNC PVT1 and AST(r=0.398, p=0.002), WBC(r=0.473, p<0.0001) in UC patients. The ROC curve analysis of LNC PVT1 revealed; LNC PVT1; AUC=0.784, P<0.0001, cut off point 1.06, sensitivity 73.3%, specificity 83.3%. Conclusion: Serum Lnc PVT1 could be used as a potential biomarker for UC diagnosis and prognosis