Spock2 is mainly produced in pancreatic stellate cells and hypermethylated in pancreatic cancer cell lines

U Aghamaliyev, K Su, Y Wu, J Werner, A Bazhin,J D’Haese

Viszeralmedizin 2021 Gemeinsame Jahrestagung Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS), Sektion Endoskopie der DGVS, Deutsche Gesellschaft für Allgemein und Viszeralchirurgie (DGAV)Zeitschrift für Gastroenterologie（2021）

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摘要

Background and aims SPOCK2, Sparc/Osteonection, cwcv, and kazal-like domains proteoglycan2, also called testican-2, is a member of the SPARC family. This gene encodes a protein, which can bind to glycosaminoglycans to form part of the extracellular matrix, and plays a role in cell adhesion and migration. In cancer, SPOCK2 was reported the first time in prostate, breast, and colon cancer and showed significantly higher methylation in cancer cells in contrast to normal prostate, breast, and colon cells. In the present study, we investigated the expression of SPOCK2 in pancreatic cancer and its possible regulation.

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