323 Treatment results of T-lymphoblastic lymphoma in children – A single-center experience

AimOur study aimed to determine the overall survival of children with non-Hodgkin T-lymphoblastic lymphoma (T-LBL), analyze and present patient characteristics and initial presentation of their disease.MethodsOur study included all patients with T-LBL non-Hodgkin lymphoma treated in the Department of Pediatrics, Division of Hematology and Oncology, University Hospital Centre Zagreb between January 1st, 2002 and December 31st, 2017. Relevant information including general patient data (gender, age at the time of diagnosis), initial clinical presentation (the presence of mediastinal masses, pericardial and pleural effusion, the presence of bone marrow and central nervous system disease) and treatment information (used therapeutic protocol and mortality data) was collected from the available medical documentation. The Kaplan-Meier curve shows patients‘ survival.ResultsOverall, 19 patients were included, 14 of which were male (73.68%) and 5 were female (26.32%). The median age at diagnosis was 10 years. 17 patients (94.44%) presented with mediastinal mass and 9 of them (52.94%) had pleural effusion. At the time of diagnosis, pericardial effusion and superior vena cava syndrome were present in 6 (33.33%) and 3 (16.67%) patients, respectively. Bone marrow involvement was detected in 10 patients (52.63%), whereas CNS involvement in only one (5.26%). 16 out of 19 patients survived (84.21%; 95% CI 67.81–100). Survival was higher for boys (85.71%) than for girls (80%), but the difference was not statistically significant (p = 0.764).ConclusionComparing general epidemiologic data with the one in the available literature we haven’t found a significant deviation of the prevalence of the disease between the sex or the median age of onset of the disease. The result of 90% five-year survival of children with T-LBL in the BFM group study was not repeated in later studies and the overall survival of 84% in our group was consistent with the results reported in the available literature.