Optical control of cellular signaling pathways using animal opsins
Biomedical Imaging and Sensing Conference 2021(2021)
摘要
Currently, in various biological research fields, optical control of cellular responses is widely utilized, leading to establishing a research field named "optogenetics". Successful optogenetic studies need both state-of-art optical devices illuminating target issues with a high spatiotemporal resolution and optical control tools (typically photosensitive proteins) driving cellular reactions in a light-dependent manner. Most of optogenetic analyses have used channelrhodopsins, light-sensitive ion channels, as control tools. Alternatively, animal opsins, light-sensitive G protein-coupled receptors, can be used as tools to drive a wide variety of G protein-dependent intracellular signaling pathways. Here, I characterize molecular properties of invertebrate opsins by spectroscopic and electrophysiological techniques, and introduce them as "ON-OFF" switch of GPCR signalings. Also, I discuss potentials of the animal opsins as optogenetic tools to expand the research field.
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关键词
opsin,G protein-coupled receptor,ion channel,optogenetics,membrane protein
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