Effective treatment of cisplatin-resistant ovarian tumors with a MoS2-based sonosensitizer and nanoenzyme capable of reversing the resistant-microenvironment and enhancing ferroptosis and apoptosis

Haoying Ge,Jianjun Du,Jiazhu Zheng,Ning Xu,Qichao Yao,Saran Long,Jiangli Fan,Xiaojun Peng

Chemical Engineering Journal（2022）

引用 13|浏览5

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摘要

•A smart MoS2-based network is proposed to completely reverse cisplatin-resistance.•HA@MoCF3Pt NPs can releases OH, SO2 and CF3 under ultrasound.•HA@MoCF3Pt NPs trigger cell apoptosis and ferroptosis to improved anti-tumor effect.

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关键词

ROS,US,·CF3,GSH,LPO,CF3SO2Na,HA,SO2,ERCC1,Bcl-2,TEM,BMIM [Cl],MB,EPR,DCFH-DA,DHE,DMPO,HPF,AO,JC-1,XRD,MTT,NaHSO3,ATP

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