A Rare Tumor in a Patient with Neurofibromatosis Type 1: Humerus Osteosarcoma

Neurofibromatosis type 1 (NF1), also known as Von Recklinghausen disease, is an autosomal dominant inherited genetic syndrome with a predisposition for a wide range of benign and malignant tumor development. Although many kinds of tumors develop in NF1 patients, osteosarcoma is seen very rarely. We report an unusual case of a 19-year-old NF1 male suffering from osteosarcoma in his humerus. The patient developed a huge mass and pathologic fracture in his left upper arm. Besides, multiple bilateral mainly ossified millimetric pulmonary metastatic lesions were detected on his chest computed tomography. In the current manuscript, we present this patient with NF1 associated osteosarcoma and review the literature.