Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.

Nikita M Patel,Filipe R M B Oliveira,Hanna Pillmann Ramos,Eleonora Aimaretti,Gustavo Ferreira Alves,Sina M Coldewey,Massimo Collino,Regina Sordi,Christoph Thiemermann

Annals of surgery（2021）

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摘要

Our results point to a role of BTK in the pathophysiology of organ injury and dysfunction caused by trauma/hemorrhage and indicate that BTK inhibitors may be repurposed as a potential therapeutic approach for MODS after trauma and/or hemorrhage.

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