Corticobasal Syndrome as Alzheimer's Disease Subtype: A Case Report

Typical Alzheimer's disease (AD) is a chronic neurodegenerative disease centered on progressive amnestic disorder. However, it may present atypically with various non-amnestic clinical profiles of other focal cortical dementia syndromes depending on the brain areas affected. One of these atypical forms is corticobasal syndrome (CBS), which is not included in the AD diagnostic criteria published by the National Institute of Aging and Alzheimer's Association in 2011 and the International Working Group 2 in 2014, but is well known by behavioral neurologists. This paper presents the case report of a 61-year-old male patient with asymmetric parkinsonism, myoclonus, pyramidal findings, primitive reflexes, and cranial imaging findings evaluated as CBS and cerebrospinal fluid biomarkers compatible with AD pathology. CBS, which is not included in the current diagnostic criteria, but is known to be associated with AD pathology in a considerable number of cases, should not be ignored in the new AD diagnostic criteria to be determined in the future.