Quantification of cyclic AMP and cyclic GMP levels in Krebs-Henseleit solution by LC-MS/MS: Application in washed platelet aggregation samples

Charles Elliot Serpellone Nash,Natalícia J. Antunes,Weverton C. Coelho-Silva,Rafael Campos,Gilberto De Nucci

SSRN Electronic Journal（2022）

引用 4|浏览2

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摘要

•For the first time, nucleotide level is measured in washed platelet by LC-MS/MS.•This method shows high precision with the lowest LLoQ to date for cAMP and cGMP.•6-Nitrodopamine does not affect platelet nucleotide levels when stimulated.

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关键词

Cyclic nucleotides,LC-MS/MS,cAMP,cGMP,Platelet aggregation,6-nitrodopamine

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