Safety and immunogenicity of the Pfizer/BioNTech SARS-CoV-2 mRNA third booster vaccine dose against the BA.1 and BA.2 Omicron variants

Yohei Seki, Yasuo Yoshihara,Kiyoko Nojima,Haruka Momose,Shuetsu Fukushi,Saya Moriyama,Ayumi Wagatsuma,Narumi Numata, Kyohei Sasaki,Tomoyo Kuzuoka, Yoshiyuki Yato,Yoshimasa Takahashi,Ken Maeda,Tadaki Suzuki,Takuo Mizukami,Isao Hamaguchi

Med（2022）

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摘要

•Neutralization titers (NTs) against Omicron decreased after two-dose mRNA vaccination•Three-dose vaccination increased anti-spike antibody and NTs against Omicron variants•Immunogenicity against Omicron subvariants did not change after three-dose vaccination•The cytokine signature remained unchanged after three-dose vaccination

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关键词

SARS-CoV-2,variant of concern,Omicron,subvariant,BA.1,BA.1.1,BA.2,BNT162b2 mRNA vaccine,neutralizing antibody,cytokine signature,adverse event

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