Three-Dimensional Topological Radiogenomics of Epidermal Growth Factor Receptor Del19 and L858R Mutation Subtypes on Computed Tomography Images of Lung Cancer Patients

Kenta Ninomiya,Hidetaka Arimura,Kentaro Tanaka,Wai Yee Chan,Yutaro Kabata,Shinichi Mizuno,Nadia Muhammad Gowdh,Nur Adura Yaakup,Chong Kin Liam,Chee-Shee Chai,Kwan Hoong Ng

SSRN Electronic Journal（2022）

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摘要

•A 3DBN-based algorithm extracted topologically invariant lung cancer CT traits.•3DBN features could feasibly classify EGFR wild-type and Del19/L858R mutations.•3DBN features showed radiogenomic associations with EGFR subtype characteristics.

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关键词

Radiogenomics,Computational topology,Molecularly targeted drugs,Precision medicine

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