Application status and research progress of animal models of knee osteoarthritis

Appropriate animal model is the basis for the smooth development of scientific research, and also the guarantee of the experimental results. As a common clinical disease, the pathogenesis of KOA and the mechanism of action of various treatment methods need to be explored and verified by a large number of animal experiments. The selection and establishment of animal model is an important link, The selection of modeling methods in western medicine and the establishment of the model of combination of disease and syndrome in traditional Chinese medicine are the key points and difficulties. In this paper, the selection of KOA animal models was reviewed through literature retrieval, and the status quo of model establishment methods was summarized from the perspectives of western medicine and TCM. The main animal species include mice, chicken, rabbit, dog, sheep, horse, pig, monkey, emu and so on. The establishment methods of western medicine and TCM models are different. Western medicine models can be divided into spontaneous model induction model and transgenic model according to different establishment methods while TCM models are mainly established according to their syndromes.