Prognostic features and comprehensive genomic analysis of NF1 mutations in EGFR mutant lung cancer patients.

Hong-Xia Tian,Zhi-Hong Chen,Guang-Ling Jie,Zhen Wang,Hong-Hong Yan,Si-Pei Wu,Shui-Lian Zhang,Dan-Xia Lu,Xu-Chao Zhang,Yi-Long Wu

Cancer medicine（2023）

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摘要

Our results indicated NF1 mutations served as a good prognostic factor in EGFR mutant/TP53 wild-type lung cancer patients in this single-center study. TP53 mutation was obviously enriched in NF1 mutant patients and had shorter OS.

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关键词

NF1 gene,TP53 gene,epidermal growth factor receptor,lung cancer,molecular typing,next-generation sequencing,overall survival

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