Functional Analysis of Wild-Type and 27 CYP3A4 Variants on Dronedarone Metabolism In vitro .
Current drug metabolism（2022）
摘要
The outcomes of this novel study on the metabolism of dronedarone by CYP3A4 alleles can be used as experimental data support for the individualized use of this modern drug.
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关键词
CYP3A4,atrial fibrillation,dronedarone,drug-metabolizing enzyme,genetic polymorphism,intrinsic clearance
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