[Characteristics of amino acid metabolism in myeloid-derived suppressor cells in septic mice].

Y Ma, Y Zhang, R Li,S W Deng,Q S Qin,L L Zhu

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences（2022）

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摘要

The enhanced mitochondrial oxidative phosphorylation, malate-aspartate shuttle and alanine metabolism in MDSCs of CLP mice may provide raw materials for mitochondrial aerobic respiration, thereby promoting the immunosuppressive function of MDSCs. Blocking the above metabolic pathways may reduce the risk of secondary infection in sepsis and improve the prognosis.

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关键词

Aerobic respiration,Amino acid metabolomics,Myeloid-derived suppressor cell,Sepsis

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