Sexual dimorphism in gut microbiota dictates therapeutic efficacy of intravenous immunoglobulin on radiotherapy complications.

Zongkui Wang,Huiwen Xiao,Jiali Dong,Yuan Li,Bin Wang,Zhiyuan Chen,Xiaozhou Zeng,Jia Liu,Yanxi Dong,Li Ma,Jun Xu,Lu Cheng,Changqing Li,Xingzhong Liu,Ming Cui

Journal of advanced research（2022）

引用 4|浏览16

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摘要

IVIg battles against radiation injuries in a sex-specific, gut microbiome-dependent way through Lachnospiraceae/hypoxanthine/PLD1 axis. Our findings provide a sex-precise therapeutic avenue to improve the prognosis of cancer patients with radiotherapy in pre-clinical settings.

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关键词

Lachnospiraceae,hypoxanthine,intravenous immunoglobulin,radiation injuries,sexual dimorphism

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