MicroRNAs miR-629-3p, miR-1202 and miR-1225-5p as potential diagnostic and surgery outcome biomarkers for mesial temporal lobe epilepsy with hippocampal sclerosis

D Gattás,F S L Neto, P Freitas-Lima, R Bonfim-Silva, S Malaquias de Almeida, M L de Assis Cirino,D Guimarães Tiezzi,L F Tirapelli,T R Velasco,A C Sakamoto,C M Matias,C G Carlotti,D P C Tirapelli

Neurochirurgie（2022）

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摘要

•miR-629-3p, miR-1202 and miR-1225-5p are involved in GABAergic pathways.•miR-629-3p, miR-1202 and miR-1225-5p are hyper-expressed in epilepsy patients’ blood.•miR-629-3p, miR-1202 and miR-1225-5p are potential diagnostic biomarkers of MTLE-HS.•miR-1202 may be a potential surgery prognose biomarker in amygdala of MTLE-HS cases.

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关键词

Mesial temporal lobe epilepsy,MicroRNA,qRT-PCR,Amygdala,Hippocampus

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