Rubicon promotes the M2 polarization of Kupffer cells via LC3-associated phagocytosis-mediated clearance to improve liver transplantation

•We reported that Rubicon-mediated LAP promotes the degradation capability of KCs to clear apoptotic T lymphocytes.•We proved that PUFAs, the product of apoptotic T cell degradation, activates PPARγ which further promotes the M2 polarization of KCs. Enhanced degradation capability mediated by Rubicon is beneficial for improving the apoptotic cell clearance of AR and promoting M2 polarization of KCs.