Methyltransferase 1 is required for nonhomologous end-joining repair and renders hepatocellular carcinoma resistant to radiotherapy.

Junbin Liao,Yang Yi,Xin Yue,Xiaoxue Wu,Meiyan Zhu,Yong Chen,Sui Peng,Ming Kuang,Shuibin Lin,Zhenwei Peng

Hepatology (Baltimore, Md.)（2022）

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摘要

Our findings show that METTL1 is a critical enhancer for HCC cell NHEJ-based DNA repair following IR therapy. These findings give insight into the role of tRNA modification in messenger RNA translation control in HCC radioresistance.

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