Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non-small cell lung cancer

Yanyan Liu,Ping Lu,Yifei Ma,Zhucheng Yin,Hongli Xu,Lanxin Xiang,Wangli Zhang,Siwei Li,Xinjun Liang

EUROPEAN JOURNAL OF IMMUNOLOGY（2022）

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摘要

Higher frequencies of polyfunctional PD1 CD8 T cells exhibited a stronger capacity to kill tumor cells in vitro and in vivo experiments. These results suggested that peripheral polyfunctional PD1 CD8 T cells demonstrated strong immune protection. This study also provided a potential combined treatment strategy with anti-PD1 and CAR-T therapy.

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关键词

NSCLC,PD1+CD8+ T cell,polyfunctional

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