[Effect of Curcumin on Apoptosis of Acute T-Lymphoblastic Leukemia Cells induced by UMI-77 and Its Related Mechanism].

Zhongguo shi yan xue ye xue za zhi（2022）

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摘要

Curcumin can enhance the apoptosis of T-ALL cells induced by Mcl-1 small molecule inhibitor UMI-77 by reducing the mitochondrial membrane potential, the mechanism may be related to the inhibition of Notch1 signaling pathway.

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关键词

Mcl-1 small molecule inhibitor,acute T-lymphoblastic leukemia,apoptosis,curcumin,mitochondrial membrane potential

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