Development of novel montmorillonite-based sustained release system for oral bromopride delivery.

Murilo L Bello, Arídio M Junior,Caroline A Freitas, Marina L A Moreira, Juliana P da Costa, Matheus A de Souza,Bianca A M C Santos,Valeria P de Sousa,Helena C Castro,Carlos R Rodrigues,Lucio M Cabral

European Journal of Pharmaceutical Sciences（2022）

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摘要

•Montmorillonite (MMT) may play a very crucial role in modulating drug delivery of class II drugs of biopharmaceutical classification system, such as bromopride.•Bromopride was successfully intercalated in the sodium-MMT and the complex showed sustained release during performed assays.•This new bromopride sustained-release system showed an alternative to improve its pharmacological performance in therapeutic applications.•Molecular dynamics simulations showed the bromopride interactions to the montmorillonite layer.

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关键词

Drug delivery system,Oral sustained release,Pharmaceutics design,Molecular modeling,Molecular dynamics simulations

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