A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern.

Panjing Lv,Bing Hu,Rong Hua,Jun Zhang,Haoran Zhang,Zhang Liu,Liqiong Xu, Zhen He,Xiang Li,Ming Guo,Kai Pan,Zhen Zhang,Qili Zeng,Zhi Wu,Li Sun,Meng Guo,Li Zhou, Xiuzhen Xu,Bo Yu,Junqiang Xu, Shuai Yuan, Min Guo, Kun Cai,Yuchen Xia, Yan Li

The Journal of infection（2022）

引用 4|浏览12

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摘要

nNovel designed protein antagonist Kansetin shows ultra-high affinity to SARS-CoV-2nKansetin exhibits broad-spectrum neutralization of SARS-CoV-2 variants of concernnKansetin has promising in vivo efficacy and non-observable toxicitynKansetin provides barely reduced potency during long-term high-temperature storage

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