The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3clpro Are Selected by a Protease Inhibitor in Vitro and Confer Resistance to Nirmatrelvir
Dirk Jochmans,Cheng Liu,Kim Donckers,Antitsa Stoycheva,Sandro Boland,Sarah K. Stevens, Chloe De Vita,Bert Vanmechelen,Piet Maes,Bettina Trueb,Nadine Ebert,Volker Thiel,Steven De Jonghe,Laura Vangeel,Dorothee Bardiot,Andreas Jekle,Lawrence M. Blatt,Leonid Beigelman,Julian A. Symons,Pierre Raboisson,Patrick Chaltin,Arnaud Marchand,Johan Neyts,Jerome Deval,Koen Vandyck mBio（2023）
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antiviral agents,coronavirus,drug resistance mechanisms,protease inhibitors
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