Evaluation of prime and prime-boost immunization strategies in BALB/c mice inoculated with Leishmania infantum transfected with toxic plasmids

Guilherme Augusto Sanches Roque,Nahiara Esteves Zorgi,Francisca Janaína Soares Rocha,Marina Flóro E Silva,Thalita Fernanda Araújo,Daniel Ruiz Abánades,Selma Giorgio

Vaccine（2022）

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摘要

•Leishmania infantum is the etiologic agent of zoonotic visceral leishmaniasis, which can be fatal.•Visceral leishmaniasis treatment may be toxic, and resistance has been reported.•There are currently no vaccines available for humans.•Transgenic L. infantum could be an excellent vaccine candidate.•Prime-boosted mice have shown maximized protection.

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关键词

Leishmaniainfantum,Immune response,Immunological protection,Transgenic Leishmania,Visceral leishmaniasis,Vaccine

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