Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 in Vivo
Rosemary Huckvale,Alice C. Harnden,Kwai-Ming J. Cheung,Olivier A. Pierrat,Rachel Talbot,Gary M. Box,Alan T. Henley,Alexis K. de Haven Brandon,Albert E. Hallsworth,Michael D. Bright,Hafize Aysin Akpinar,Daniel S. J. Miller,Dalia Tarantino,Sharon Gowan,Angela Hayes,Emma A. Gunnell,Alfie Brennan,Owen A. Davis, Louise D. Johnson,Selby de Klerk,Craig McAndrew,Yann-Vai Le Bihan,Mirco Meniconi,Rosemary Burke,Vladimir Kirkin,Rob L. M. van Montfort,Florence I. Raynaud,Olivia W. Rossanese,Benjamin R. Bellenie,Swen Hoelder JOURNAL OF MEDICINAL CHEMISTRY（2022）
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Cereblon-Dependent Degradation
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