Interactions in CSF1-Driven Tenosynovial Giant Cell Tumors.

David G P van IJzendoorn,Magdalena Matusiak,Gregory W Charville,Geert Spierenburg,Sushama Varma, Deana R C Colburg,Michiel A J van de Sande,Kirsten van Langevelde,David G Mohler,Kristen N Ganjoo,Nam Q Bui,Raffi S Avedian,Judith V M G Bovée,Robert Steffner,Robert B West,Matt van de Rijn

Clinical cancer research : an official journal of the American Association for Cancer Research（2022）

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摘要

The neoplastic cells in TGCT are highly similar to nonneoplastic synoviocytes. The lack of CSF1R on the neoplastic cells indicates they may be unaffected by current therapies. High expression of GFPT2 in the neoplastic cells is associated with activation of the YAP1/TAZ pathway. In addition, we identified expression of the platelet-derived growth factor receptor in the neoplastic cells. These findings suggest two additional pathways to target in this tumor.

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tenosynovial giant cell tumors

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