SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation

David N Hanna,Paula Marincola Smith,Sergey V Novitskiy,M Kay Washington,Jinghuan Zi,Connie J Weaver,Jalal A Hamaamen,Keeli B Lewis,Jing Zhu,Jing Yang,Qi Liu,R Daniel Beauchamp,Anna L Means

Gastroenterology（2022）

引用 5|浏览8

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摘要

The SMAD4 tumor suppressor gene regulates communication between colon cells and surrounding immune cells. In the setting of colitis, SMAD4 loss leads to increased immune cells and promotes tumor development.

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关键词

Inflammatory Bowel Disease,Colorectal Cancer,SMAD4,Inflammation

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