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879 Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer

Akash Patnaik,Kiranj Chaudagar,Hanna Hieromnimon,Taghreed Hirz,Shenglin Mei,David Sykes

Clinical cancer research : an official journal of the American Association for Cancer Research（2022）

Cited 14|Views33
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Abstract
Immunometabolic strategies that reverse lactate and PD-1-mediated TAM immunosuppression, in combination with ADT, warrant further investigation in PTEN-deficient mCRPC patients.
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Key words
macrophage immunosuppression controls growth,prostate cancer,lactate
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