Culture-Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids.

Rachel D Edgar,Francesca Perrone,April R Foster,Felicity Payne,Sophia Lewis,Komal M Nayak,Judith Kraiczy, Aurélie Cenier,Franco Torrente,Camilla Salvestrini,Robert Heuschkel,Kai O Hensel,Rebecca Harris,D Leanne Jones,Daniel R Zerbino,Matthias Zilbauer

Cellular and molecular gastroenterology and hepatology（2022）

引用 5|浏览13

暂无评分

摘要

Our study shows distinct culture-associated epigenetic changes in mucosa-derived human IEOs, some of which appear to impact gene transcriptomic and cellular function. These findings highlight the need for future studies in this area and the importance of considering passage number as a potentially confounding factor.

查看译文

关键词

Culture Conditions,Epigenetics,Intestinal Epithelium,Organoid

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要