Statin and metformin use and outcomes in patients with castration-resistant prostate cancer treated with enzalutamide: A meta-analysis of AFFIRM, PREVAIL and PROSPER

Anthony M. Joshua,Andrew Armstrong,Megan Crumbaker,Howard I. Scher,Johann de Bono,Bertrand Tombal,Maha Hussain,Cora N. Sternberg,Silke Gillessen,Joan Carles,Karim Fizazi,Ping Lin,William Duggan,Jennifer Sugg,David Russell,Tomasz M. Beer

European Journal of Cancer（2022）

引用 7|浏览14

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摘要

•No consistent association between statin/metformin and survival outcomes was found.•Concomitant statin and enzalutamide use may be associated with a lower risk of death.•Further prospective, controlled studies in these patients are warranted.

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关键词

Enzalutamide,Castration-resistant prostate cancer,Statin,Metformin,Radiographic progression-free survival,Overall survival

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