Development and Internal Validation of a Prognostic Model of the Probability of Death or Lung Transplantation Within 2 Years for Patients With Cystic Fibrosis and FEV1 ≤ 50% Predicted

Among individuals with CF and FEV ≤ 50% predicted, FEV percent predicted, oxygen therapy, and number of pulmonary exacerbations predicted 2-year death or LTx. Although limited by small sample size, only FEV remained predictive in patients receiving highly effective modulator therapy. Additional physiologic variables could improve prognostication in CF.