Comparative single-cell RNA-sequencing profiling of BMP4-treated primary glioma cultures reveals therapeutic markers.

Iris S C Verploegh,Andrea Conidi,Rutger W W Brouwer,Hayri E Balcioglu,Panagiotis Karras,Samira Makhzami,Anne Korporaal,Jean-Christophe Marine,Martine Lamfers,Wilfred F J Van IJcken,Sieger Leenstra,Danny Huylebroeck

Neuro-oncology（2022）

引用 7|浏览21

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摘要

The changes in composition of patient-derived GBM cultures obtained after treatment with BMP4 correlate with treatment efficacy. OLIG1/2 expression can predict this efficacy, and upregulation of RPL27A and RPS27 are useful early-response markers.

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关键词

BMP,drug therapy,glioblastoma,single-cell RNA-sequencing,tumor heterogeneity

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