Inquiring the librarian about the location of memory.

Where memories are stored in the brain is an age-old question in psychology and neuroscience alike. In particular, whether hippocampus-encoded memories are transferred to the cortex or remain hippocampus-dependent over time has not been definitely answered. New evidence from fMRI studies in humans suggest that while hippocampo-cortical connections lose weight during declarative memory consolidation, the hippocampus - alongside corticocortical connections - stays equally engaged between recent and remote memory recall. These findings lend experimental support for the indexing theory of memory consolidation, which postulates the hippocampus to act as a librarian to retrieve the cortical books of memory.