Effectiveness of 10 and 13-valent pneumococcal conjugate vaccines against invasive pneumococcal disease in European children: SpIDnet observational multicentre study

•PCV10 and PCV13 protect similarly against invasive disease due to vaccine serotypes.•PCV13 provides direct protection against serotype 3 and vaccine-related serotype 6C.•PCV10 does not provide significant protection against vaccine-related serotypes 19A and 6C.•PCV13 effectiveness declined with time after booster, in particular for serotypes 3 and 19A.•Multinational networks are crucial for the evaluation of PCV15/ PCV20 that may be introduced.