Enhanced stability and oral bioavailability of erlotinib by solid self nano emulsifying drug delivery systems

Sanyog Jain,Kiran Dongare,Bhargavi Nallamothu,Chander Parkash Dora,Varun Kushwah,Sameer S Katiyar,Reena Sharma

International Journal of Pharmaceutics（2022）

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摘要

•A200-ERL-sSNEDDS formulation was found to be robust in terms of stability against several folds dilution in the gastrointestinal tract (GIT)•A200-ERL-sSNEDDS increased cytotoxicity and apoptosis in PANC-1 and MIA PaCa-2 cells.•Pharmacokinetic studies revealed ∼2.2 times increase in AUC0-∞values in case of A200-ERL-sSNEDDS as compare to free ERL.

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MTT,6-CFDA,ANOVA,AnnCy3,BCS,CPM,MIA PaCa-2,CMR,DSC,DMSO,DMEM,EGFR,ERL,FBS,GIT,Caco-2,PANC-1,HPMC,LBF,MWCO,PVP,PXRD,RP-HPLC,rpm,SEM,SEDDS,SGF,SIF,TEM,UV spectroscopy

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