5-Nitroindazole derivatives as potential therapeutic alternatives against Acanthamoeba castellanii

Rubén Martín-Escolano,Gregorio Pérez-Cordón,Vicente J Arán,Clotilde Marín,Manuel Sánchez-Moreno,María José Rosales

Acta Tropica（2022）

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摘要

•Antiparasitic activity of 5-nitroindazole derivatives.•In vitro evaluation against trophozoite and cyst forms of Acanthamoeba castellanii.•Improved biological activity than the reference drug chlorhexidine digluconate.•Compound 8 is a potential alternative for the treatment of A. castellanii infection.

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关键词

Acanthamoeba castellanii,Amoebicidal,Chlorhexidine digluconate,5-nitroindazole derivatives

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