N6-methyladenosine-modified RNA acts as a molecular glue that drives liquid-liquid phase separation in plants.
PLANT SIGNALING & BEHAVIOR(2022)
摘要
Liquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N6-methyladenosine (m6A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m6A-reader proteins contain putative prion-like domains, and the ect2/3/4 mutant exhibited reduced formation of key nuclear and cytoplasmic condensates in Arabidopsis.
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关键词
Liquid-liquid phase separation, m6A modification, m6A reader, ECT
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