Flow-based allergen testing: Can mast cells beat basophils?

Didier G. Ebo,Kevin Heremans,Michiel Beyens,Marie-Line M. van der Poorten,Athina L. Van Gasse,Christel Mertens,Michel Van Houdt,Vito Sabato,Jessy Elst

Clinica Chimica Acta（2022）

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摘要

•The basophil activation test (BAT) has evolved to a safe and reliable diagnostic.•The BAT has some limitations hindering wider application.•The mast cell activation test (MAT) appears a promising adjunct diagnostic.•The MAT does not necessitate viable patients’ cells and allows lager batch analyses.•Unlike BAT, MAT can directly reveal potential MRGPRX2 agonistic activity.

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关键词

Mast cells,Basophils,Hypersensitivity,Flow cytometry,MRGPRX2,IgE

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