Impact of concomitant fibrates on immunotherapy outcomes for advanced non-small cell lung cancer.

William A Stokes,Madhusmita Behera,Renjian Jiang,David A Gutman,Zhonglu Huang,Abigail Burns, Nikhil T Sebastian,Vidula Sukhatme,Michael C Lowe,Suresh S Ramalingam,Vikas P Sukhatme,Drew Moghanaki

Cancer medicine（2022）

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摘要

Concomitant fibrates are associated with improved OS among NSCLC patients receiving ICI but not among those receiving chemotherapy. This hypothesis-generating observation supports a potential role for fibrates as an adjunct to immunotherapy.

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关键词

fibrates,immune checkpoint inhibitors,peroxisome proliferator-activated receptor (PPAR) agonists

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