Leveraging physiologically based pharmacokinetic modeling to optimize dosing for lopinavir/ritonavir with rifampin in pediatric patients.

Sara N Salerno,Edmund V Capparelli,Helen McIlleron,Jacqueline G Gerhart,Julie B Dumond,Angela D M Kashuba,Paolo Denti,Daniel Gonzalez

Pharmacotherapy（2022）

引用 1|浏览19

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摘要

Super-boosted LPV/RTV with 15 mg/kg rifampin achieves therapeutic LPV troughs in HIV/TB-infected simulated children.

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关键词

drug-drug interactions (DDI),human immunodeficiency virus (HIV),lopinavir (LPV),pediatric,physiologically based pharmacokinetic modeling (PBPK),rifampicin,ritonavir (RTV),tuberculosis (TB)

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