Management of immune-related hepatitis in patients being treated with checkpoint inhibitors for metastatic melanoma, a review and case series.

Alice Tew,Leila Khoja,Lalit Pallan,Neil Steven

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners（2022）

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摘要

This study describes the largest UK series of immune-related hepatitis patients in the literature. We present two important deviations from current guidelines. Firstly, there is some evidence that withholding steroids is possible in grade 3-4 immune-related hepatitis. Secondly, tacrolimus can be used successfully to manage patients resistant to corticosteroids, with the early introduction most beneficial to reduce time on steroids.

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关键词

Checkpoint inhibitors,immune-related adverse events,immune-related hepatitis,melanoma,tacrolimus

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