The influence of a glucose administration on stress responsivity and memory after a socially evaluated cold pressor test

The nutritional state of participants prior to stress induction via a laboratory stressor has been demonstrated to influence reactivity of the Hypothalamus-Pituitary-Adrenal axis. So far, either primarily psychosocial or primarily physiological stressors have been utilized investigating this effect. In the present study, we aimed to fill this gap in the existing literature by utilizing a stressor that combines both elements, namely the Socially Evaluated Cold Pressor Test. Furthermore, we investigated how glucose consumption and subsequent stress induction influence long-term memory retrieval as well as working memory. In a 2 × 2 design, half of the 72 participants (36 women, 36 men) participated in the laboratory stressor while the other half participated in a control condition after having fasted for at least six hours. Thirty minutes prior to stress or control treatment, fasted participants consumed either 75 g of glucose or stevia-sweetened water. Salivary cortisol levels, systolic and diastolic blood pressure, as well as affect did not significantly differ between participants consuming glucose or the placebo beverage. Acute stress impaired working memory but had no effect on long-term memory retrieval. Glucose consumption did not significantly influence memory. Our results suggest that the intensity of a stressor might be important when determining the effects of a glucose administration on stress reactivity. The nutritional state of participants taking part in studies investigating the effects of acute stress on memory might be less decisive than previously assumed.