Phytosomal tripterine with selenium modification attenuates the cytotoxicity and restrains the inflammatory evolution via inhibiting NLRP3 inflammasome activation and pyroptosis

Shaomin Liu, Qiufang Chen,Liang Yan,Yuehong Ren,Jun Fan,Xingwang Zhang,Shiping Zhu

International Immunopharmacology（2022）

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摘要

•Tripterine was formulated into nanoscale phytosomes followed by selenium modification.•Selenized phytosomes attenuated the cytotoxicity of tripterine in macrophages.•Selenized phytosomal Tri could effectively inhibit NLRP3 inflammasome activation.•Se@Tri-TPs suppressed ATP-induced NLRP3 inflammasome activation and pyroptosis.

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关键词

Tripterine,Phytosomes,Selenium,Inflammasome,Pyroptosis,Macrophages

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